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I started Savella a little over a month ago and had not experienced any side effects until the last two weeks. Palpitations/ elevated resting heart rate and right sided headaches, which I did not realize were due to this medication because I didn't experience any initial side effects. Overall muscle pain has been greatly reduced, energy increased. Bummed out that I may have to stop due to the new side effects.
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Starting Savella in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of serotonin syndrome.
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Some medications that can affect serotonin include: (tramadol), triptans (used as a Migraine abortive), MAOIs (a class of antidepressants), and antipsychotics.
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There are no well-controlled studies that have been done in humans with Savella, though.
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WARNING: Although not used for depression, this medication is in the same class as antidepressant medications.
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Side effects were terrible at first (severe nausea, agitation and vomiting) but once I got past them and as long as I do not miss a dose, I am fine.
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Savella should be prescribed with caution in patients with a history of a seizure disorder, mania or controlled narrow-angle glaucoma.
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However, seizures have been reported infrequently in patients treated with Savella for disorders other than fibromyalgia.
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Remember that Savella is just an antidepressant that is marketed as a fibromyalgia treatment.
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One needs to remember that this data comes from two trials only three months in duration in which the second, larger trial specifically excluded patients with moderate or severe depression.
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